vcCNT is a homotrimer transmembrane protein with three identical subunits positioned in a triangle. Each subunit can bind and transport nucleosides. Each subunit is an …

vcCNT is a homotrimer transmembrane protein with three identical subunits positioned

in a triangle. Each subunit can bind and transport nucleosides. Each subunit is an alpha-helical

protein containing mostly transmembrane alpha helices and a few that span the surface of the

membrane (figure 1). The alpha helices are arranged in roughly two subdomains: the scaffold

domain (red in figure 1f)(helices TM1, TM2, IH1, EH, TM3, and TM6) that forms a ring around

the central transport domain which is formed of two groups of helices (IH2, HP1a/b, TM4a/b and

TM5 in one, IH3, HP2a/b, TM7a/b, and TM8 in the other). These two groups have structural

symmetry. The structural domain is responsible for maintaining the overall structure of the

protein and aids trimerization, while the transport domain contains Na+ and uridine binding sites.

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