vcCNT is a homotrimer transmembrane protein with three identical subunits positioned
in a triangle. Each subunit can bind and transport nucleosides. Each subunit is an alpha-helical
protein containing mostly transmembrane alpha helices and a few that span the surface of the
membrane (figure 1). The alpha helices are arranged in roughly two subdomains: the scaffold
domain (red in figure 1f)(helices TM1, TM2, IH1, EH, TM3, and TM6) that forms a ring around
the central transport domain which is formed of two groups of helices (IH2, HP1a/b, TM4a/b and
TM5 in one, IH3, HP2a/b, TM7a/b, and TM8 in the other). These two groups have structural
symmetry. The structural domain is responsible for maintaining the overall structure of the
protein and aids trimerization, while the transport domain contains Na+ and uridine binding sites.
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